Eddie Valiant lands a plum job as Gary Cooper’s bodyguard while Coop scouts locations for his next movie—a screwball comedy titled Hi, Toon! But Eddie’s dream job quickly turns into a nightmare. The film’s being shot in Toontown, and Coop’s co-star turns out to be none other than Roger Rabbit. Eddie’s a big fan of Coop. Of Roger? Not so much.
A sinister hoodlum threatens to murder Coop if the movie gets made. Before long, Eddie, Coop, Roger, and the ever-glamorous Jessica Rabbit are embroiled in a mystery that could destroy Toontown.